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KMID : 0869619960130040309
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Journal of Korean Society of Hospital Pharmacists
1996 Volume.13 No. 4 p.309 ~ p.315
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Amikacin Pharmacokinetics and Proposed Dosing Modification in Korean Neonates
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이은경/Lee, Eun Kyung
김정선/최경업/장윤실/박원순/Kim, Jung Sun/Choi, Kyung Eob/Chang, Yun Sil/Park, Won Soon
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Abstract
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The pharmacokinetic(PK) parameters of amikacin were evaluated in 28 Korean neonates. The NEOFAX regimen was used to determine the amikacin dose that was administered intravenously over 30 minutes by a syringe pump. The peak and trough levels of amikacin were measured at steady-state and analyzed by fluorescence polarization immunoassay. PK parameters were computed by utilizing one-compartment open model and Kruskal-Wallis test was used for statistical analysis. The calculated volume of distribution(Vd) and half-life(t_(1/2)) in the neonates were 0.52±0.15L/㎏ and 5.6±3.2 hrs, respectively. Linear correlations were found between the postconceptional age(PCA)and clearance(CL=-0.1312+0.0057PCA; r=0.74; P=0.0001), and between PCA and half-life(t_(1/2)=22.38-0.4379PCA; r=-0.90; p=0.0001). Since 78.8% of measured peak levels were subtherapeutic, most neonates required higher amikacin doses. In case of neonates whose gestational age(GA) was 30-36 weeks, the dosing interval was shortened to achieve optimal peak levels.
Based on these PK data we propose using modified NEOFAX regimen, which needs to be confirmed by further prospective study.
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KEYWORD
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